A 10-year cohort analysis of routine paediatric ART data in a rural South African setting.
| Autor: | Lilian RR; Anova Health Institute,Johannesburg and Tzaneen,South Africa., Mutasa B; Anova Health Institute,Johannesburg and Tzaneen,South Africa., Railton J; Anova Health Institute,Johannesburg and Tzaneen,South Africa., Mongwe W; Mopani Department of Health,Giyani,South Africa., McINTYRE JA; Anova Health Institute,Johannesburg and Tzaneen,South Africa., Struthers HE; Anova Health Institute,Johannesburg and Tzaneen,South Africa., Peters RP; Anova Health Institute,Johannesburg and Tzaneen,South Africa. |
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| Jazyk: | angličtina |
| Zdroj: | Epidemiology and infection [Epidemiol Infect] 2017 Jan; Vol. 145 (1), pp. 170-180. Date of Electronic Publication: 2016 Sep 09. |
| DOI: | 10.1017/S0950268816001916 |
| Abstrakt: | South Africa's paediatric antiretroviral therapy (ART) programme is managed using a monitoring and evaluation tool known as TIER.Net. This electronic system has several advantages over paper-based systems, allowing profiling of the paediatric ART programme over time. We analysed anonymized TIER.Net data for HIV-infected children aged <15 years who had initiated ART in a rural district of South Africa between 2005 and 2014. We performed Kaplan-Meier survival analysis to assess outcomes over time. Records of 5461 children were available for analysis; 3593 (66%) children were retained in care. Losses from the programme were higher in children initiated on treatment in more recent years (P < 0·0001) and in children aged ≤1 year at treatment initiation (P < 0·0001). For children aged <3 years, abacavir was associated with a significantly higher rate of loss from the programme compared to stavudine (hazard ratio 1·9, P < 0·001). Viral load was suppressed in 48-52% of the cohort, with no significant change over the years (P = 0·398). Analysis of TIER.Net data over time provides enhanced insights into the performance of the paediatric ART programme and highlights interventions to improve programme performance. |
| Databáze: | MEDLINE |
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