Oral administration of an aqueous extract from the oyster mushroom Pleurotus ostreatus enhances the immunonutritional recovery of malnourished mice.

Autor: Llauradó G; Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba. Electronic address: gabriel@uo.edu.cu., Morris HJ; Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba., Lebeque Y; Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba., Venet G; Faculty of Medicine No. 2, Medical University of Santiago de Cuba, Santiago de Cuba 4, CP 90400, Cuba., Fong O; Centre of Toxicology and Biomedicine, Medical University of Santiago de Cuba, Autopista Nacional Km 1 1/2, Apdo Postal 4033, Santiago de Cuba, Cuba., Marcos J; Centre of Toxicology and Biomedicine, Medical University of Santiago de Cuba, Autopista Nacional Km 1 1/2, Apdo Postal 4033, Santiago de Cuba, Cuba., Fontaine R; Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba., Cos P; Laboratory for Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium., Bermúdez RC; Centre of Studies for Industrial Biotechnology, University of Oriente, Ave. Patricio Lumumba s/n, Reparto Jiménez, Santiago de Cuba, 5, CP 90 500, Cuba.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2016 Oct; Vol. 83, pp. 1456-1463. Date of Electronic Publication: 2016 Sep 06.
DOI: 10.1016/j.biopha.2016.08.067
Abstrakt: Mushroom nutriceutical components have lately attracted interest for developing immunonutritional support. However, there is relatively little information pertaining to the use of mushroom preparations for modulating the metabolic and immunological disorders associated to malnutrition. This study was aimed to evaluate the effects of oral administration of an aqueous extract (CW-P) from Pleurotus ostreatus on the recovery of biochemical and immunological functions of malnourished mice. 8-week old female BALB/c mice were starved for 3days and then refed with commercial diet supplemented with or without CW-P (100mg/kg) for 8days. Regardless of the diet used during refeeding, animal body weights and serum protein concentrations did not differ between groups. Oral treatment with CW-P normalized haemoglobin levels, liver arginase and gut mucosal weight. CW-P increased total liver proteins and also DNA and protein contents in gut mucosa. Pleurotus extract provided benefits in terms of macrophages activation as well as in haemopoiesis, as judged by the recovery of bone marrow cells and leukocyte counts. Moreover, CW-P stimulated humoral immunity (T-dependent and T non-dependent antibodies responses) compared to non-supplemented mice. CW-P extract from the oyster mushroom can be used to develop specific food or nutritional supplement formulations with potential clinical applications in the immunotherapy.
(Copyright © 2016 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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