Tumor Heterogeneity Detected by 68Ga DOTATOC and 18F-FDG PET/CTs in One Malignant Insulinoma With Involvement of the Portal Splenic Confluence and Ovarian Metastases.

Autor: Bélissant Benesty O; From the *Department of Nuclear Medicine, Hôpital Tenon APHP and UPMC Sorbonne University, Paris; †Department of Nuclear Medicine, Hôpitaux Tenon and Saint Antoine APHP and UPMC Sorbonne University, Paris; and ‡Department of Endocrinology, Hôpital Saint Antoine APHP and UPMC Sorbonne University, Paris, France., Cassou-Mounat T, Vatier C, Talbot JN, Montravers F
Jazyk: angličtina
Zdroj: Clinical nuclear medicine [Clin Nucl Med] 2016 Nov; Vol. 41 (11), pp. 874-876.
DOI: 10.1097/RLU.0000000000001360
Abstrakt: A 67-year-old woman was referred for staging of an insulinoma. CT has shown a pancreatic tumor, a portal thrombus, and an ovarian mass presumed not to be related with the insulinoma. These three lesions were highly positive on Ga DOTATOC PET/CT, leading to the hypothesis of a malignant insulinoma with neoplastic vein thrombus and ovarian metastasis, which was subsequently confirmed histologically. Despite severe hypoglycemia preventing fasting, F-FDG PET/CT was informative, showing significant uptake by the thrombus, which corresponded to the most aggressive lesion (Ki67 of 3.5% for the primary pancreatic tumor and 19.6% for the thrombus).
Databáze: MEDLINE