Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients.

Autor: Cemil BC; Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey., Ayvaz HH; Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey., Ozturk G; Department of Biochemistry, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey., Ergin C; Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey., Akıs HK; Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey., Gonul M; Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey., Arzuhal E; Department of Biochemistry, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Postepy dermatologii i alergologii [Postepy Dermatol Alergol] 2016 Aug; Vol. 33 (4), pp. 294-9. Date of Electronic Publication: 2016 Aug 16.
DOI: 10.5114/pdia.2016.56928
Abstrakt: Introduction: Isotretinoin has been successfully used for the treatment of acne vulgaris.
Aim: To investigate the effects of isotretinoin on body mass index (BMI), to determine whether isotretinoin causes any changes in serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients, and to correlate variables.
Material and Methods: Thirty-two patients were included in this study. Oral isotretinoin was begun at a dose of 0.5-0.6 mg/kg and raised to 0.6-0.75 mg/kg. Pretreatment and posttreatment third-month BMI and adiponectin, leptin, and ghrelin serum levels were measured.
Results: The pre- and posttreatment BMI values were not significantly different. In addition, serum adiponectin and leptin levels were significantly increased following isotretinoin therapy while serum ghrelin levels were not different.
Conclusions: Isotretinoin may exert its anti-inflammatory activity by increasing leptin and adiponectin levels.
Databáze: MEDLINE
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