| Autor: |
Souza NC; 1 Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte , Natal, RN, Brazil ., de Oliveira JM; 1 Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte , Natal, RN, Brazil ., Morrone MDS; 2 Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil ., Albanus RD; 3 Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA ., Amarante MDSM; 4 Department of Morphology, Federal University of Rio Grande do Norte, Natal, RN, Brazil ., Camillo CDS; 4 Department of Morphology, Federal University of Rio Grande do Norte, Natal, RN, Brazil ., Langassner SMZ; 4 Department of Morphology, Federal University of Rio Grande do Norte, Natal, RN, Brazil ., Gelain DP; 2 Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil ., Moreira JCF; 2 Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil ., Dalmolin RJS; 1 Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte , Natal, RN, Brazil ., de Bittencourt Pasquali MA; 1 Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte , Natal, RN, Brazil .; 5 Department of Food Engineering, Federal University of Campina Grande, Campina Grande, PB, Brazil . |
| Abstrakt: |
In South America, particularly in the Northeastern regions of Brazil, Turnera subulata leaf extract is used as an alternative traditional medicine approach for several types of chronic diseases, such as diabetes, hypertension, chronic pain, and general inflammation. Despite its widespread use, little is known about the medicinal properties of the plants of this genus. In this study, we evaluate the antioxidant and anti-inflammatory of T. subulata leaf extract in an in vitro model of inflammation, using lipopolysaccharide-stimulated RAW-264.7 macrophage cell line. We observed that cotreatment with T. subulata leaf extract was able to reduce the oxidative stress in cells due to inflammatory response. More importantly, we observed that the leaf extract was able to directly modulate inflammatory response by altering activity of members of the mitogen-activated protein kinase pathways. Our results demonstrate for the first time that T. subulata have antioxidant and anti-inflammatory properties, which warrant further investigation of the medicinal potential of this species. |
