mRNA expression profile of mouse oligodendrocytes in inflammatory conditions.

Autor:	Kudriaeva AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia., Khaustova NA; BioKlinikum Scientific-Technical Center LLC, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088, Russia., Maltseva DV; BioKlinikum Scientific-Technical Center LLC, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088, Russia., Kuzina ES; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia., Glagoleva IS; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, ul. Karla Marksa 74, Kazan, Tatarstan, 420055, Russia., Surina EA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia., Knorre VD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia. vera.knorre@gmail.com., Belogurov AA Jr; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, ul. Karla Marksa 74, Kazan, Tatarstan, 420055, Russia., Tonevitsky AG; BioKlinikum Scientific-Technical Center LLC, ul. Ugreshskaya 2, bdg. 85, Moscow, 115088, Russia., Gabibov AG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, 117997, Russia.; Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, ul. Karla Marksa 74, Kazan, Tatarstan, 420055, Russia.; Faculty of Chemistry, Moscow State University, Moscow, 119991, Russia.
Jazyk:	angličtina
Zdroj:	Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2016 Jul; Vol. 469 (1), pp. 264-8. Date of Electronic Publication: 2016 Sep 07.
DOI:	10.1134/S1607672916040086
Abstrakt:	In this study, we performed transcriptome profiling of oligodendrocyte culture of mice treated with the remyelinating therapeutic agent benztropine in the presence and absence of interferon gamma (IFNγ). The results of this work are important for understanding the expression profile of oligodendrocytes under conditions of systemic inflammation in the central nervous system in multiple sclerosis as well as the mechanisms of cellular response to benztropine in light of its possible use for the treatment of multiple sclerosis.
Databáze:	MEDLINE
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