Influence of the use of testosterone associated with physical training on some hematologic and physical parameters in older rats with alloxan-induced diabetes.

Autor:	Silva RP; Centro de Ciências da Saúde e Desporto, Universidade Federal do Acre (UFAC), Rio Branco, AC, Brasil.; Centro Universitário do Planalto de Araxá (Uniaraxá), Araxá, MG, Brasil., Santos RO; Centro Universitário do Planalto de Araxá (Uniaraxá), Araxá, MG, Brasil., Matildes NE Junior; Centro Universitário do Planalto de Araxá (Uniaraxá), Araxá, MG, Brasil., Mundim AV; Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brasil., Garrote-Filho MD; Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brasil., Rodrigues PF; Centro Universitário do Planalto de Araxá (Uniaraxá), Araxá, MG, Brasil., Penha-Silva N; Instituto de Genética e Bioquímica, Universidade Federal de Uberlândia (UFU), Uberlândia, MG, Brasil.
Jazyk:	angličtina
Zdroj:	Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2017 Jan-Feb; Vol. 61 (1), pp. 62-69. Date of Electronic Publication: 2016 Sep 05.
DOI:	10.1590/2359-3997000000200
Abstrakt:	Objective: This study investigated the possible blood changes in wistar rats elderly with and without treatment with anabolic steroids submitted physical training. Materials and Methods: Elderly rats (32) were divided into four groups: normal (N), treated normal (NT), diabetic (D) and treated diabetic (DT). They were submitted to 20 sessions of swimming with overload (5% body weight), 40 min/day for four weeks. The NT and DT groups received application of testosterone twice a week. At the end of the sessions, the animals were subjected to swimming until exhaustion and then killed for removal of blood and visceral fat. We evaluated maximum swim time, weight of visceral fat, erythrogram, leukogram, lipidogram and serum levels of glucose, lactate, aspartate aminotransferase and creatine kinase. The results were compared using one-way ANOVA followed by the post hoc Tukey test. Results: In elderly diabetic rats, the use of anabolic associated with physical training in older rats resulted in improvement in erythrogram, lipidogram and physical performance for high-intensity aerobic exercise. However, it was related to changes in leukocyte count, probably associated with inflammation. Conclusion: The combination of the use of testosterone with physical training, followed by maximal effort test caused changes hematological and biochemical can be associated with improvement in physiological characteristics, with increase of the swimming time and decrease of visceral fat levels, improvement in aerobic metabolism of fatty acids and glucose in normal and diabetic animals.
Databáze:	MEDLINE
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