Fibrinolysis parameters in Sudanese women with severe preeclampsia.

Autor: Elzein HO; a Faculty of Medical Laboratory Sciences , Al-ZaiemAl-Azhari University , Khartoum , Sudan., Muddathir AR; a Faculty of Medical Laboratory Sciences , Al-ZaiemAl-Azhari University , Khartoum , Sudan., Rida M; a Faculty of Medical Laboratory Sciences , Al-ZaiemAl-Azhari University , Khartoum , Sudan., Rayis DA; b Faculty of Medicine , University of Khartoum , Khartoum , Sudan., Elhassan EM; c Faculty of Medicine , University of Geziera , Medani , Sudan., Adam I; b Faculty of Medicine , University of Khartoum , Khartoum , Sudan.
Jazyk: angličtina
Zdroj: Hypertension in pregnancy [Hypertens Pregnancy] 2016 Nov; Vol. 35 (4), pp. 559-564. Date of Electronic Publication: 2016 Sep 06.
DOI: 10.1080/10641955.2016.1211676
Abstrakt: Background: Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia.
Objectives: A case-control study was conducted in Medani Hospital, Sudan, to investigate thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen-activated inhibitor (PAI) in women with severe preeclampsia. Obstetrics and medical history was gathered using questionnaire. TAFI, PAI-1, and PAI-2 levels were measured using ELISA.
Results: In comparison with the controls, women with severe preeclampsia had significantly higher levels [mean (SD)] of TAFI [3.4 (1.1) vs. 3.0(0.7) ng/ml, P = 0.019], PAI-1 [3.2 (1.3) vs. 2.5(1.0), IU/ml, P = 0.001], and significantly lower PAI-2 level [4.2(1.3) vs. 5.8(2.6) ng/ml, P < 0.001]. In linear regression, severe preeclampsia was significantly associated with TAFI (0.408 ng/ml, P = 0.038), PAI-1 (0.722, IU/ml P = 0.003), and PAI-2 (-1.745, ng/ml, P < 0.001).
Conclusion: The current study revealed a significant increase level of TAFI and PAI-1, coupled with a decrease in PAI-2 in women with severe preeclampsia in comparison with the control group.
Databáze: MEDLINE
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