Gamma radiation at a human relevant low dose rate is genotoxic in mice.

Autor: Graupner A; Department of Chemicals and Radiation, Norwegian Institute of Public Health, Oslo 0403, Norway.; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Eide DM; Department of Chemicals and Radiation, Norwegian Institute of Public Health, Oslo 0403, Norway.; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Instanes C; Department of Chemicals and Radiation, Norwegian Institute of Public Health, Oslo 0403, Norway.; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Andersen JM; Department of Chemicals and Radiation, Norwegian Institute of Public Health, Oslo 0403, Norway.; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Brede DA; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway.; Department of Environmental Sciences (IMV), Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Dertinger SD; Litron Laboratories, Rochester, NY 14623, United States., Lind OC; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway.; Department of Environmental Sciences (IMV), Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Brandt-Kjelsen A; Department of Environmental Sciences (IMV), Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Bjerke H; Department of Monitoring and Research, Norwegian Radiation Protection Authority, Østerås 1332, Norway., Salbu B; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway.; Department of Environmental Sciences (IMV), Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Oughton D; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway.; Department of Environmental Sciences (IMV), Norwegian University of Life Sciences (NMBU), Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Brunborg G; Department of Chemicals and Radiation, Norwegian Institute of Public Health, Oslo 0403, Norway.; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway., Olsen AK; Department of Chemicals and Radiation, Norwegian Institute of Public Health, Oslo 0403, Norway.; Centre for Environmental Radioactivity (CoE CERAD), Ås 1432, Norway.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2016 Sep 06; Vol. 6, pp. 32977. Date of Electronic Publication: 2016 Sep 06.
DOI: 10.1038/srep32977
Abstrakt: Even today, 70 years after Hiroshima and accidents like in Chernobyl and Fukushima, we still have limited knowledge about the health effects of low dose rate (LDR) radiation. Despite their human relevance after occupational and accidental exposure, only few animal studies on the genotoxic effects of chronic LDR radiation have been performed. Selenium (Se) is involved in oxidative stress defence, protecting DNA and other biomolecules from reactive oxygen species (ROS). It is hypothesised that Se deficiency, as it occurs in several parts of the world, may aggravate harmful effects of ROS-inducing stressors such as ionising radiation. We performed a study in the newly established LDR-facility Figaro on the combined effects of Se deprivation and LDR γ exposure in DNA repair knockout mice (Ogg1(-/-)) and control animals (Ogg1(+/-)). Genotoxic effects were seen after continuous radiation (1.4 mGy/h) for 45 days. Chromosomal damage (micronucleus), phenotypic mutations (Pig-a gene mutation of RBC(CD24-)) and DNA lesions (single strand breaks/alkali labile sites) were significantly increased in blood cells of irradiated animals, covering three types of genotoxic activity. This study demonstrates that chronic LDR γ radiation is genotoxic in an exposure scenario realistic for humans, supporting the hypothesis that even LDR γ radiation may induce cancer.
Competing Interests: S.D.D. is an employee of Litron Laboratories; Litron holds patents covering flow cytometric methods for scoring GPI anchor-deficient erythrocytes and sells kits based on this technology (In Vivo MutaFlow); Litron holds patents covering flow cytometric methods for scoring micronucleated erythrocytes and sells kits based on this technology (In Vivo MicroFlow).
Databáze: MEDLINE
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