Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4 lps-2J /J mouse cortex.

Autor: Ramos RL; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA. Electronic address: rramos02@nyit.edu., Toia AR; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA., Pasternack DM; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA., Dotzler TP; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA., Cuoco JA; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA., Esposito AW; Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA., Le MM; Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610-0244, USA., Parker AK; Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610-0244, USA., Goodman JH; Department of Developmental Neurobiology, NY State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA; Department of Physiology & Pharmacology and Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA., Sarkisian MR; Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610-0244, USA. Electronic address: msarkisian@ufl.edu.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2016 Nov 19; Vol. 337, pp. 48-65. Date of Electronic Publication: 2016 Sep 03.
DOI: 10.1016/j.neuroscience.2016.08.049
Abstrakt: Subcortical band heterotopia (SBH) are malformations of the human cerebral cortex typically associated with epilepsy and cognitive delay/disability. Rodent models of SBH have demonstrated strong face validity as they are accompanied by both cognitive deficits and spontaneous seizures or reduced seizure threshold. BXD29-Tlr4 lps-2J /J recombinant inbred mice display striking bilateral SBH, partial callosal agenesis, morphological changes in subcortical structures of the auditory pathway, and display sensory deficits in behavioral tests (Rosen et al., 2013; Truong et al., 2013, 2015). Surprisingly, these mice show no cognitive deficits and have a higher seizure threshold to chemi-convulsive treatment (Gabel et al., 2013) making them different than other rodent SBH models described previously. In the present report, we perform a detailed characterization of the cellular and axonal constituents of SBH in BXD29-Tlr4 lps-2J /J mice and demonstrate that various types of interneurons and glia as well as cortical and subcortical projections are found in SBH. In addition, the length of neuronal cilia was reduced in SBH compared to neurons in the overlying and adjacent normotopic cortex. Finally, we describe additional and novel malformations of the hippocampus and neocortex present in BXD29-Tlr4 lps-2J /J mice. Together, our findings in BXD29-Tlr4 lps-2J /J mice are discussed in the context of the known neuroanatomy and phenotype of other SBH rodent models.
(Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE