| Autor: |
Poletaeva II; Moscow State University, Moscow, 199991, Russia. ingapoletaeva@mail.ru., Perepelkina OV; Moscow State University, Moscow, 199991, Russia., Boyarshinova OS; Moscow State University, Moscow, 199991, Russia., Golibrodo VA; Moscow State University, Moscow, 199991, Russia., Lilp IG; Moscow State University, Moscow, 199991, Russia., Lipp HP; Institute of Anatomy, University of Zürich, Zürich, Switzerland.; School of Laboratory Medicine, Kwazulu-Natal University, Durban, South Africa., Shin HS; Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Republic of Korea. |
| Abstrakt: |
Mice with a knockout of the sodium-calcium exchanger 2 (NCX2) gene were statistically significantly more successful than wild-type controls in the solution of two cognitive tasks, the test for the capacity to extrapolate the direction of the stimulus movement and the "puzzle-box" test for the capacity to find a hidden route to safe environment, which were based on food and aversive motivations, respectively. In both tests, the success of task solution was based on the animal's ability to use the object's "permanence" rule (according to J. Piaget). The data confirm that the knockout of this gene, which is accompanied by modulation of the temporal pattern of calcium membrane flux, also induces changes in mouse CNS plasticity. |
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