| Autor: |
Mikashinovich ZI; Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia., Belousova ES; Department of Pharmaceutical Chemistry and Pharmacology, Rostov State Medical University, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia. belousovalena@mail.ru. |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Aug; Vol. 161 (4), pp. 600-3. Date of Electronic Publication: 2016 Sep 03. |
| DOI: |
10.1007/s10517-016-3467-2 |
| Abstrakt: |
Long-term administration of simvastatin to rats, irrespective of the baseline cholesterol levels, induced biochemical changes in erythrocytes attesting to hypoxic damage (accumulation of lactate and 2,3-diphosphoglycerate), disturbances in ATP-dependent mechanisms of ion homeostasis regulation (decrease in total ATPase and Ca(2+)-ATPase activities), and antioxidant enzymes system imbalance. These changes can be considered as a sensitive indicator and molecular basis of cell damage during long-term administration of statins. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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