Simple direct formation of self-assembled N-heterocyclic carbene monolayers on gold and their application in biosensing.

Autor:	Crudden CM; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6.; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya 464-8602, Japan., Horton JH; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6., Narouz MR; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6., Li Z; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6., Smith CA; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6., Munro K; Protein Function Discovery Facility, Queen's University, Kingston, Ontario, Canada K7L 3N6., Baddeley CJ; EaStCHEM School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, UK., Larrea CR; EaStCHEM School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, UK., Drevniok B; Department of Physics, Engineering Physics and Astronomy, Queen's University, Kingston, Ontario, Canada K7L 3N6., Thanabalasingam B; Department of Physics, Engineering Physics and Astronomy, Queen's University, Kingston, Ontario, Canada K7L 3N6., McLean AB; Department of Physics, Engineering Physics and Astronomy, Queen's University, Kingston, Ontario, Canada K7L 3N6., Zenkina OV; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6., Ebralidze II; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6.; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada M1C 1A4., She Z; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada M1C 1A4., Kraatz HB; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario, Canada M1C 1A4.; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6., Mosey NJ; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6., Saunders LN; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, Canada K7L 3N6., Yagi A; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2016 Sep 02; Vol. 7, pp. 12654. Date of Electronic Publication: 2016 Sep 02.
DOI:	10.1038/ncomms12654
Abstrakt:	The formation of organic films on gold employing N-heterocyclic carbenes (NHCs) has been previously shown to be a useful strategy for generating stable organic films. However, NHCs or NHC precursors typically require inert atmosphere and harsh conditions for their generation and use. Herein we describe the use of benzimidazolium hydrogen carbonates as bench stable solid precursors for the preparation of NHC films in solution or by vapour-phase deposition from the solid state. The ability to prepare these films by vapour-phase deposition permitted the analysis of the films by a variety of surface science techniques, resulting in the first measurement of NHC desorption energy (158±10 kJ mol(-1)) and confirmation that the NHC sits upright on the surface. The use of these films in surface plasmon resonance-type biosensing is described, where they provide specific advantages versus traditional thiol-based films.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu