Body mass index and all-cause mortality among older adults.

Autor: Cheng FW; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA., Gao X; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA. xxg14@psu.edu., Mitchell DC; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA., Wood C; Department of Internal Medicine & the Obesity Institute, Geisinger Health System, Danville, Pennsylvania, USA., Still CD; Department of Internal Medicine & the Obesity Institute, Geisinger Health System, Danville, Pennsylvania, USA., Rolston D; Department of Internal Medicine & the Obesity Institute, Geisinger Health System, Danville, Pennsylvania, USA., Jensen GL; Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA.; Dean's Office and Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2016 Oct; Vol. 24 (10), pp. 2232-9. Date of Electronic Publication: 2016 Aug 29.
DOI: 10.1002/oby.21612
Abstrakt: Objective: To examine the association between baseline body mass index (BMI, kg/m(2) ) and all-cause mortality in a well-characterized cohort of older persons.
Methods: The association between BMI (both as a categorical and continuous variable) and all-cause mortality was investigated using 4,565 Geisinger Rural Aging Study participants with baseline age 74.0 ± 4.7 years (mean ± SD) and BMI 29.5 ± 5.3 kg/m(2) over a mean of 10.9 ± 3.8 years of follow-up.
Results: The relationship between BMI (as a continuous variable) and all-cause mortality was found to be U-shaped (P nonlinearity <0.001). Controlling for age, sex, smoking, alcohol, laboratory values, medications, and comorbidity status, underweight (BMI <18.5 kg/m(2) ) individuals had significantly greater adjusted risk of all-cause mortality than persons of BMI 18.5 to 24.9 kg/m(2) (reference range). Participants with overweight (BMI 25.0-29.9 kg/m(2) ) and class I obesity (BMI 30.0-34.9 kg/m(2) ) had significantly lower adjusted-risk of all-cause mortality. Those with classes II/III obesity (BMI ≥ 35.0 kg/m(2) ) did not have significantly greater adjusted-risk of all-cause mortality. Findings were consistent using propensity score weights and among never-smokers with 2- and 5-year lag analysis and among those with no identified chronic disease.
Conclusions: A U-shaped association was observed between BMI and all-cause mortality with lower risk among older persons with overweight and class I obesity in comparison with those with BMI 18.5 to 24.9 kg/m(2) .
(© 2016 The Obesity Society.)
Databáze: MEDLINE
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