Phase-stable swept source OCT angiography in human skin using an akinetic source.

Autor:	Chen Z; Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria., Liu M; Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria., Minneman M; Insight Photonic Solutions, Inc., 300 S. Public Rd., Lafayette CO 80026, USA., Ginner L; Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine, Währinger Gürtel 18-20, 1090 Vienna, Austria., Hoover E; Insight Photonic Solutions, Inc., 300 S. Public Rd., Lafayette CO 80026, USA., Sattmann H; Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Insight Photonic Solutions, Inc., 300 S. Public Rd., Lafayette CO 80026, USA., Bonesi M; Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria., Drexler W; Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria., Leitgeb RA; Center of Medical Physics and Biomedical Engineering, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria; Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2016 Jul 12; Vol. 7 (8), pp. 3032-48. Date of Electronic Publication: 2016 Jul 12 (Print Publication: 2016).
DOI:	10.1364/BOE.7.003032
Abstrakt:	We demonstrate noninvasive structural and microvascular contrast imaging of human skin in vivo, using phase difference swept source OCT angiography (pOCTA). The pOCTA system employs an akinetic, all-semiconductor, highly phase-stable swept laser source which operates at 1340 nm central wavelength, with 37 nm bandwidth (at 0 dB region) and 200 kHz A-scan rate. The phase sensitive detection does not need any external phase stabilizing implementations, due to the outstanding high phase linearity and sweep phase repeatability within 2 mrad. We compare the performance of phase based OCTA to speckle based OCTA for visualizing human vascular networks. pOCTA shows better contrast especially for deeper vascular details as compared to speckle based OCTA. The phase stability of the akinetic source allows the OCTA system to show decent vascular contrast only with 2 B-scans. We compare the performance of using 2 versus 4 B-scans for calculating the vascular contrast. Finally, the performance of a 100 nm bandwidth akinetic laser at 1310 nm is investigated for both OCT and OCTA.
Databáze:	MEDLINE
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