Percutaneous CT-Guided Cryoablation of the Salivary Glands in a Porcine Model.

Autor:	Buethe JY; Department of Diagnostic and Interventional Radiology, Johns Hopkins Hospitals, Baltimore, Maryland., Abboud S; Department of Diagnostic and Interventional Radiology, University Hospitals Case Medical Center, Cleveland, Ohio., Brock K; Department of Veterinary Medicine, Case Western Reserve University, Cleveland, Ohio., Nizialek G; Department of Diagnostic and Interventional Radiology, University Hospitals Case Medical Center, Cleveland, Ohio., Rezaee R; Department of Head and Neck Reconstructive Surgery, University Hospitals Case Medical Center, Cleveland, Ohio., Wasman J; Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio., Frankel J; Department of Head and Neck Reconstructive Surgery, University Hospitals Case Medical Center, Cleveland, Ohio., Nakamoto DA; Department of Diagnostic and Interventional Radiology, University Hospitals Case Medical Center, Cleveland, Ohio. Electronic address: Dean.Nakamoto@uhhospitals.org.
Jazyk:	angličtina
Zdroj:	Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2016 Dec; Vol. 27 (12), pp. 1907-1912. Date of Electronic Publication: 2016 Aug 24.
DOI:	10.1016/j.jvir.2016.06.002
Abstrakt:	Purpose: To evaluate the imaging, histologic changes and safety of computed tomography (CT)-guided cryoablation of the parotid glands in a porcine model. Materials and Methods: Unilateral CT-guided parotid gland cryoablation was performed in 5 juvenile miniature pigs. The ablated parotid glands underwent 2 cycles of 10-minute freeze and 5-minute thaw using three 17-g cryoprobes. The animals were monitored daily for complications including pain, frostbite, infection, and sialocele or fistula formation. Follow-up CT was performed at 6 weeks postcryoablation. Pathologic evaluation was performed on 2 of the ablated parotid glands. Results: All cryoablations in 5 right parotid glands, with 3 sites in each gland, were technically successful. No symptoms suggestive of facial nerve damage were observed during 6-week follow-up. One pig developed an infected sialocele, which was treated with percutaneous drainage and oral antibiotic therapy. No CT evidence of sialocele or other abnormality was identified at the 6-week follow-up in all pigs. Histologic evaluation was performed on 2 of the parotid gland specimens, 1 with the treated sialocele, and 1 of the remaining pigs without sialocele. Both glands demonstrated postprocedural intraglandular lymph nodes and reactive changes without evidence of sialocele or abscess on histopathology. Conclusions: Cryoablation of parotid glands was technically feasible in a porcine model. Only 1 pig developed sialocele, which was successfully treated. Further research is warranted to determine the potential use of salivary gland cryoablation to treat patients with drooling. (Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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