DNA-binding studies of the natural β-carboline eudistomin U.

Autor: Giulietti JM; Providence College, Department of Chemistry and Biochemistry, 1 Cunningham Square, Providence, RI 02918, USA., Tate PM; Providence College, Department of Chemistry and Biochemistry, 1 Cunningham Square, Providence, RI 02918, USA., Cai A; University of Rhode Island, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, 7 Greenhouse Road, Kingston, RI 02881, USA., Cho B; University of Rhode Island, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, 7 Greenhouse Road, Kingston, RI 02881, USA., Mulcahy SP; Providence College, Department of Chemistry and Biochemistry, 1 Cunningham Square, Providence, RI 02918, USA. Electronic address: smulcahy@providence.edu.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Oct 01; Vol. 26 (19), pp. 4705-4708. Date of Electronic Publication: 2016 Aug 18.
DOI: 10.1016/j.bmcl.2016.08.047
Abstrakt: Eudistomin U is a member of the β-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple β-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV-Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: