Myelitis and Lupus: Clinical Manifestations, Diagnosis and Treatment. Review.

Autor:	Chiganer EH; Unidad de Inmunología e Histocompatibilidad, Hospital Carlos Durand, Buenos Aires, Argentina. Electronic address: edsonchiganer@gmail.com., Hryb JP; Unidad de Inmunología e Histocompatibilidad, Hospital Carlos Durand, Buenos Aires, Argentina; Servicio de Neurología, Hospital Carlos Durand, Buenos Aires, Argentina., Carnero Contentti E; Servicio de Neurología, Hospital Carlos Durand, Buenos Aires, Argentina.
Jazyk:	English; Spanish; Castilian
Zdroj:	Reumatologia clinica [Reumatol Clin] 2017 Nov - Dec; Vol. 13 (6), pp. 344-348. Date of Electronic Publication: 2016 Aug 24.
DOI:	10.1016/j.reuma.2016.06.004
Abstrakt:	Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple systems. Myelopathy is one of 19 neuropsychiatric syndromes related to SLE defined by the American College of Rheumatology. Although infrequent, it is a severe manifestation, leading to motor and sensory deficits, and sphincter dysfunction. The pathogenesis is not clearly known, but may be related to arterial thrombosis and vasculitis. Diagnosis is based on clinical findings, laboratory tests and the use of gadolinium-enhanced magnetic resonance imaging. The standard therapy is the combination of intravenous cyclophosphamide and glucocorticoids. In refractory disease, other treatments such as plasmapheresis or rituximab have been used. (Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
Databáze:	MEDLINE
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