Tissue engineering and regenerative medicine in musculoskeletal oncology.

Autor: Holzapfel BM; Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4049, Australia. holzapfel@orthopaedic-oncology.net.; Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, 97072, Wuerzburg, Germany. holzapfel@orthopaedic-oncology.net., Wagner F; Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4049, Australia.; Department of Orthopaedics, University Regensburg, Asklepios Clinic Bad Abbach, Kaiser-Karl V.-Allee 3, 93077, Bad Abbach, Germany.; Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Lindwurmstraße 4, 80337, Munich, Germany., Martine LC; Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4049, Australia., Reppenhagen S; Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, 97072, Wuerzburg, Germany., Rudert M; Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, 97072, Wuerzburg, Germany., Schuetz M; Department of Trauma and Reconstructive Surgery, Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Campus Virchow, Augustenburger Pl. 1, 13353, Berlin, Germany., Denham J; School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia., Schantz JT; Department of Plastic Surgery and Hand Surgery, University Clinic Rechts der Isar, Technical University Munich, Ismaningerstr. 22, 81675, Munich, Germany.; School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459, Singapore., Hutmacher DW; Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4049, Australia. dietmar.hutmacher@qut.edu.au.; George W Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 801 Ferst Drive Northwest, Atlanta, GA, 30332, USA. dietmar.hutmacher@qut.edu.au.; Institute for Advanced Study, Technical University Munich, Lichtenbergstraße 2a, 85748, Garching, Munich, Germany. dietmar.hutmacher@qut.edu.au.
Jazyk: angličtina
Zdroj: Cancer metastasis reviews [Cancer Metastasis Rev] 2016 Sep; Vol. 35 (3), pp. 475-87.
DOI: 10.1007/s10555-016-9635-z
Abstrakt: Currently used surgical techniques to reconstruct tissue defects after resection of musculoskeletal tumours are associated with high complication rates. This drives a strong demand for innovative therapeutic concepts that are able to improve the clinical outcomes of patients suffering from bone and soft tissue tumours. Tissue engineering and regenerative medicine (TE&RM) provides a technology platform based on biochemical, molecular, cellular and biomaterials modules to selectively direct tissue healing processes for improved defect regeneration. At the same time, precautionary measures have to be taken when these instruments are used in cancer patients to prevent any promotion of tumour growth or metastatic spread. On the other hand, several innovative TE&RM tools are being developed such as multi-functionalized biomaterials, drug-delivering nanomaterials or genetically engineered stem cells that per se have the potential to mediate anti-cancer effects, act synergistically with currently used chemotherapeutics and/or radiotherapy regimens and reduce their side effects. Recently, scientists became conscious that TE&RM strategies may not only be utilized to advance contemporary tissue reconstruction techniques but also to develop personalized diagnostic tools and clinically relevant disease models for cancer patients. Eventually, prospective randomized clinical trials combined with comparative outcome analyses are a conditio sine qua non to shape the benefits of personalized regenerative therapies for the standardized management of patients with musculoskeletal tumours.
Databáze: MEDLINE
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