| Autor: |
Kaufmann D; 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA., Theriot JJ; 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.; 2 Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA., Zyuzin J; 2 Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA., Service CA; 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA., Chang JC; 3 Rehabilitation Medicine Department, Mark O. Hatfield Clinical Research Center, National Institutes of Health, Bethesda, MD, USA.; 4 Mathematical Biosciences Institute, The Ohio State University, Columbus, OH, USA., Tang YT; 5 Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, USA., Bogdanov VB; 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.; 6 Department of Neurology, University of Liège, Liège, Belgium., Multon S; 6 Department of Neurology, University of Liège, Liège, Belgium., Schoenen J; 6 Department of Neurology, University of Liège, Liège, Belgium., Ju YS; 5 Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, CA, USA., Brennan KC; 1 Department of Neurology, University of Utah, Salt Lake City, UT, USA.; 2 Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA. |
| Abstrakt: |
Spreading depolarizations are implicated in a diverse set of neurologic diseases. They are unusual forms of nervous system activity in that they propagate very slowly and approximately concentrically, apparently not respecting the anatomic, synaptic, functional, or vascular architecture of the brain. However, there is evidence that spreading depolarizations are not truly concentric, isotropic, or homogeneous, either in space or in time. Here we present evidence from KCl-induced spreading depolarizations, in mouse and rat, in vivo and in vitro, showing the great variability that these depolarizations can exhibit. This variability can help inform the mechanistic understanding of spreading depolarizations, and it has implications for their phenomenology in neurologic disease. |
