| Autor: |
Montenegro-Burke JR, Phommavongsay T, Aisporna AE, Huan T, Rinehart D, Forsberg E, Poole FL; Department of Biochemistry and Molecular Biology, University of Georgia , Athens, Georgia 30602, United States., Thorgersen MP; Department of Biochemistry and Molecular Biology, University of Georgia , Athens, Georgia 30602, United States., Adams MW; Department of Biochemistry and Molecular Biology, University of Georgia , Athens, Georgia 30602, United States., Krantz G; Department of Microbiology and Immunology and Center for Biofilm Engineering, Montana State University , 109 Lewis Hall, Bozeman, Montana 59717, United States., Fields MW; Department of Microbiology and Immunology and Center for Biofilm Engineering, Montana State University , 109 Lewis Hall, Bozeman, Montana 59717, United States., Northen TR; Life Sciences Division, Lawrence Berkeley National Laboratory , 1 Cyclotron Road, Berkeley, California 94720, United States., Robbins PD; Departments of Metabolism and Aging, The Scripps Research Institute-Florida , Jupiter, Florida 33458, United States., Niedernhofer LJ; Departments of Metabolism and Aging, The Scripps Research Institute-Florida , Jupiter, Florida 33458, United States., Lairson L, Benton HP, Siuzdak G |
| Abstrakt: |
Active data screening is an integral part of many scientific activities, and mobile technologies have greatly facilitated this process by minimizing the reliance on large hardware instrumentation. In order to meet with the increasingly growing field of metabolomics and heavy workload of data processing, we designed the first remote metabolomic data screening platform for mobile devices. Two mobile applications (apps), XCMS Mobile and METLIN Mobile, facilitate access to XCMS and METLIN, which are the most important components in the computer-based XCMS Online platforms. These mobile apps allow for the visualization and analysis of metabolic data throughout the entire analytical process. Specifically, XCMS Mobile and METLIN Mobile provide the capabilities for remote monitoring of data processing, real time notifications for the data processing, visualization and interactive analysis of processed data (e.g., cloud plots, principle component analysis, box-plots, extracted ion chromatograms, and hierarchical cluster analysis), and database searching for metabolite identification. These apps, available on Apple iOS and Google Android operating systems, allow for the migration of metabolomic research onto mobile devices for better accessibility beyond direct instrument operation. The utility of XCMS Mobile and METLIN Mobile functionalities was developed and is demonstrated here through the metabolomic LC-MS analyses of stem cells, colon cancer, aging, and bacterial metabolism. |
