High trans but not saturated fat beverage causes an acute reduction in postprandial vascular endothelial function but not arterial stiffness in humans.

Autor:	Lane-Cordova AD; Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA., Witmer JR; Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA., Dubishar K; Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA., DuBose LE; Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA., Chenard CA; Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA., Siefers KJ; Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA., Myers JE; Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA., Points LJ; Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA., Pierce GL; Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA gary-pierce@uiowa.edu.; Fraternal Order of Eagles Diabetes Research Center, The University of Iowa, Iowa City, IA, USA.; Center for Hypertension Research, The University of Iowa, Iowa City, IA, USA.; Abboud Cardiovascular Research Center, The University of Iowa, Iowa City, IA, USA.
Jazyk:	angličtina
Zdroj:	Vascular medicine (London, England) [Vasc Med] 2016 Oct; Vol. 21 (5), pp. 429-436. Date of Electronic Publication: 2016 Aug 23.
DOI:	10.1177/1358863X16656063
Abstrakt:	A diet high in trans-fatty acids (TFAs) is associated with a higher risk of cardiovascular disease (CVD) than a diet high in saturated fatty acids (SFAs), but the mechanisms remain unclear. We hypothesized that a beverage high in TFAs would cause a larger reduction in postprandial endothelial function and an increase in arterial stiffness, in part from greater reductions in insulin sensitivity, compared with a beverage high in SFAs. Eleven healthy adults (aged 47±5 years) ingested a warm test beverage (520 kcal, 56 g total fat, 5 g carbohydrate, 1 g protein) high in either TFAs or SFAs in a randomized cross-over study. Ingestion of the beverage high in TFAs (p<0.01) but not high in SFAs (p=0.49) decreased endothelial function (brachial artery flow-mediated dilation, mmΔ) at 3-4 hours (p<0.01 for time; p=0.034 for interaction), but did not alter aortic stiffness or carotid β-stiffness. The homeostasis model of insulin resistance (interaction p=0.062) tended to decrease after SFAs but not TFAs. A beverage high in TFAs but not SFAs results in a postprandial reduction in endothelial function and a trend for decreased insulin sensitivity, potentially explaining the higher risk of CVD with a diet high in TFAs. (© The Author(s) 2016.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu