| Autor: |
Valente GT; Department of Bioprocess and Biotechnology, Agronomic Science School, UNESP - Sao Paulo State University, Botucatu, SP, 18610-307, Brazil., Nakajima RT; Department of Morphology, Institute of Biosciences, UNESP - Sao Paulo State University, Sao Paulo, Botucatu, 18618-689, Brazil., Fantinatti BE; Department of Morphology, Institute of Biosciences, UNESP - Sao Paulo State University, Sao Paulo, Botucatu, 18618-689, Brazil., Marques DF; Department of Morphology, Institute of Biosciences, UNESP - Sao Paulo State University, Sao Paulo, Botucatu, 18618-689, Brazil., Almeida RO; Department of Bioprocess and Biotechnology, Agronomic Science School, UNESP - Sao Paulo State University, Botucatu, SP, 18610-307, Brazil., Simões RP; Department of Bioprocess and Biotechnology, Agronomic Science School, UNESP - Sao Paulo State University, Botucatu, SP, 18610-307, Brazil., Martins C; Department of Morphology, Institute of Biosciences, UNESP - Sao Paulo State University, Sao Paulo, Botucatu, 18618-689, Brazil. cmartins@ibb.unesp.br. |
| Abstrakt: |
Though hundreds to thousands of reports have described the distribution of B chromosomes among diverse eukaryote groups, a comprehensive theory of their biological role has not yet clearly emerged. B chromosomes are classically understood as a sea of repetitive DNA sequences that are poor in genes and are maintained by a parasitic-drive mechanism during cell division. Recent developments in high-throughput DNA/RNA analyses have increased the resolution of B chromosome biology beyond those of classical and molecular cytogenetic methods; B chromosomes contain many transcriptionally active sequences, including genes, and can modulate the activity of autosomal genes. Furthermore, the most recent knowledge obtained from omics analyses, which is associated with a systemic view, has demonstrated that B chromosomes can influence cell biology in a complex way, possibly favoring their own maintenance and perpetuation. |
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