Transient glutathione depletion in the substantia nigra compacta is associated with neuroinflammation in rats.

Autor: Díaz-Hung ML; International Center for Neurological Restoration (CIREN), Havana, Cuba. Electronic address: mldiaz@neuro.ciren.cu., Yglesias-Rivera A; Pharmaceutics Biological Laboratories (LABIOFAM), Havana, Cuba., Hernández-Zimbrón LF; Research Department, Asociación para Evitar la Ceguera 'Hospital Luis Sanchez Bulnes', IAP. México City 04030, Mexico., Orozco-Suárez S; Specialty Hospital from Neurological Diseases, CMN, SXXI, IMSS, Mexico., Ruiz-Fuentes JL; Tropical Medicine 'Pedro Kourí' Institute (IPK), Havana, Cuba., Díaz-García A; Pharmaceutics Biological Laboratories (LABIOFAM), Havana, Cuba., León-Martínez R; International Center for Neurological Restoration (CIREN), Havana, Cuba., Blanco-Lezcano L; International Center for Neurological Restoration (CIREN), Havana, Cuba., Pavón-Fuentes N; International Center for Neurological Restoration (CIREN), Havana, Cuba., Lorigados-Pedre L; International Center for Neurological Restoration (CIREN), Havana, Cuba.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2016 Oct 29; Vol. 335, pp. 207-20. Date of Electronic Publication: 2016 Aug 20.
DOI: 10.1016/j.neuroscience.2016.08.023
Abstrakt: Glutathione (GSH) deficiency has been identified as an early event in the progression of Parkinson's disease. However, the role of GSH in the etiology and pathogenesis of this neurodegenerative disorder is not well established. The aim of this study is to assess the effect of transient GSH depletion in the substantia nigra pars compacta (SNpc) on neuroinflammation after the injection of a single dose of l-buthionine sulfoximine (BSO) into the SNpc of male Sprague-Dawley rats. The results showed that BSO treatment stimulates microglia (p<0.01) and astroglial response (p<0.01), c-Jun N-terminal kinase and inducible nitric oxide synthase (iNOS) (p<0.001) in the SNpc, accompanied by dopaminergic dysfunction. In addition, high levels of tumor necrosis factor α (p<0.01), interleukins IL-1β p<0.01), IL-6 p<0.001) and nitric oxide p<0.01) were found in the treated animals compared to control groups, while no significant differences were found in IL-10 levels. These results suggest that transient GSH depletion can increase the susceptibility of SNpc to degeneration by promoting an inflammatory response and nitrosative stress, reinforcing the possible role of GSH unbalance, oxygen/nitrogen reactive species and neuroinflammation as causal factors on the degeneration of the SNpc.
(Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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