The presence of Campylobacter pylori in nonsteroidal antiinflammatory drug associated gastritis.

Autor: Iglehart IW 3rd; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD., Edlow DW, Mills L Jr, Morrison SA, Hochberg MC
Jazyk: angličtina
Zdroj: The Journal of rheumatology [J Rheumatol] 1989 May; Vol. 16 (5), pp. 599-603.
Abstrakt: Although Campylobacter pylori has recently been causally linked to active chronic gastritis and peptic ulcer disease, its relationship to nonsteroidal antiinflammatory drug (NSAID) associated gastritis is unclear. We performed a case-control study of 100 patients who had undergone gastritis biopsy. Blinded review of Giemsa stained slides demonstrated the presence of C. pylori in 32% of 19 NSAID treated cases with active chronic gastritis vs 3% of 36 controls with chronic gastritis not taking NSAID, and 69% of 45 "positive" controls with active chronic gastritis not taking NSAID (p less than 0.001). Our results suggest a possible multifactorial etiology of NSAID associated gastritis.
Databáze: MEDLINE