Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity.

Autor: Drew Sayer R; Department of Nutrition Science, Purdue University, West Lafayette, Indiana, USA., Tamer GG Jr; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA., Chen N; Department of Statistics, Purdue University, West Lafayette, Indiana, USA., Tregellas JR; Department of Psychiatry, University of Colorado School of Medicine, Aurora, Colorado, USA., Cornier MA; Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA., Kareken DA; Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Talavage TM; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, USA., McCrory MA; Department of Nutrition, Georgia State University, Atlanta, Georgia, USA., Campbell WW; Department of Nutrition Science, Purdue University, West Lafayette, Indiana, USA. campbellw@purdue.edu.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2016 Oct; Vol. 24 (10), pp. 2057-63. Date of Electronic Publication: 2016 Aug 20.
DOI: 10.1002/oby.21603
Abstrakt: Objective: The brain's reward system influences ingestive behavior and subsequently obesity risk. Functional magnetic resonance imaging (fMRI) is a common method for investigating brain reward function. This study sought to assess the reproducibility of fasting-state brain responses to visual food stimuli using BOLD fMRI.
Methods: A priori brain regions of interest included bilateral insula, amygdala, orbitofrontal cortex, caudate, and putamen. Fasting-state fMRI and appetite assessments were completed by 28 women (n = 16) and men (n = 12) with overweight or obesity on 2 days. Reproducibility was assessed by comparing mean fasting-state brain responses and measuring test-retest reliability of these responses on the two testing days.
Results: Mean fasting-state brain responses on day 2 were reduced compared with day 1 in the left insula and right amygdala, but mean day 1 and day 2 responses were not different in the other regions of interest. With the exception of the left orbitofrontal cortex response (fair reliability), test-retest reliabilities of brain responses were poor or unreliable.
Conclusions: fMRI-measured responses to visual food cues in adults with overweight or obesity show relatively good mean-level reproducibility but considerable within-subject variability. Poor test-retest reliability reduces the likelihood of observing true correlations and increases the necessary sample sizes for studies.
(© 2016 The Obesity Society.)
Databáze: MEDLINE
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