Is it possible to find presence of lactose in pharmaceuticals? - Preliminary studies by ATR-FTIR spectroscopy and chemometrics.

Autor: Banas A; Singapore Synchrotron Light Source, 5 Research Link, 117603 Singapore, Singapore. Electronic address: slsba@nus.edu.sg., Banas K; Singapore Synchrotron Light Source, 5 Research Link, 117603 Singapore, Singapore., Kalaiselvi SMP; Singapore Synchrotron Light Source, 5 Research Link, 117603 Singapore, Singapore., Pawlicki B; Gabriel Narutowicz Hospital, Pradnicka 37, 31-202 Krakow, Poland., Kwiatek WM; Institute of Nuclear Physics PAN, Radzikowskiego 152, 31-342 Krakow, Poland., Breese MBH; Singapore Synchrotron Light Source, 5 Research Link, 117603 Singapore, Singapore.
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2017 Jan 15; Vol. 171, pp. 280-286. Date of Electronic Publication: 2016 Aug 04.
DOI: 10.1016/j.saa.2016.08.003
Abstrakt: Lactose and saccharose have the same molecular formula; however, the arrangement of their atoms is different. A major difference between lactose and saccharose with regard to digestion and processing is that it is not uncommon for individuals to be lactose intolerant (around two thirds of the population has a limited ability to digest lactose after infancy), but it is rather unlikely to be saccharose intolerant. The pharmaceutical industry uses lactose and saccharose as inactive ingredients of drugs to help form tablets because of their excellent compressibility properties. Some patients with severe lactose intolerance may experience symptoms of many allergic reactions after taking medicine that contains this substance. People who are specifically "allergic" to lactose (not just lactose intolerant) should not use tablets containing this ingredient. Fourier Transform Infrared (FTIR) spectroscopy has a unique chemical fingerprinting capability and plays a significant important role in the identification and characterization of analyzed samples and hence has been widely used in pharmaceutical science. However, a typical FTIR spectrum collected from tablets contains a myriad of valuable information hidden in a family of tiny peaks. Powerful multivariate spectral data processing can transform FTIR spectroscopy into an ideal tool for high volume, rapid screening and characterization of even minor tablet components. In this paper a method for distinction between FTIR spectra collected for tablets with or without lactose is presented. The results seem to indicate that the success of identifying one component in FTIR spectra collected for pharmaceutical composition (that is tablet) is largely dependent on the choice of the chemometric technique applied.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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