Spatiotemporal structure of intracranial electric fields induced by transcranial electric stimulation in humans and nonhuman primates.

Autor: Opitz A; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA.; Center for the Developing Brain, Child Mind Institute, New York, USA., Falchier A; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA., Yan CG; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA.; Key Laboratory of Behavioral Science and Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China., Yeagle EM; Department of Neurosurgery, Hofstra Northwell School of Medicine, and Feinstein Institute for Medical Research, Manhasset, NY, USA., Linn GS; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA.; Department of Psychiatry, NYU Langone School of Medicine, NY, USA., Megevand P; Department of Neurosurgery, Hofstra Northwell School of Medicine, and Feinstein Institute for Medical Research, Manhasset, NY, USA., Thielscher A; Danish Research Center for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark.; Max Planck Institute for Biological Cybernetics, Tübingen, Germany.; Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark., Deborah A R; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA., Milham MP; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA.; Center for the Developing Brain, Child Mind Institute, New York, USA., Mehta AD; Department of Neurosurgery, Hofstra Northwell School of Medicine, and Feinstein Institute for Medical Research, Manhasset, NY, USA., Schroeder CE; Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA.; Departments of Neurological Surgery and Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2016 Aug 18; Vol. 6, pp. 31236. Date of Electronic Publication: 2016 Aug 18.
DOI: 10.1038/srep31236
Abstrakt: Transcranial electric stimulation (TES) is an emerging technique, developed to non-invasively modulate brain function. However, the spatiotemporal distribution of the intracranial electric fields induced by TES remains poorly understood. In particular, it is unclear how much current actually reaches the brain, and how it distributes across the brain. Lack of this basic information precludes a firm mechanistic understanding of TES effects. In this study we directly measure the spatial and temporal characteristics of the electric field generated by TES using stereotactic EEG (s-EEG) electrode arrays implanted in cebus monkeys and surgical epilepsy patients. We found a small frequency dependent decrease (10%) in magnitudes of TES induced potentials and negligible phase shifts over space. Electric field strengths were strongest in superficial brain regions with maximum values of about 0.5 mV/mm. Our results provide crucial information of the underlying biophysics in TES applications in humans and the optimization and design of TES stimulation protocols. In addition, our findings have broad implications concerning electric field propagation in non-invasive recording techniques such as EEG/MEG.
Databáze: MEDLINE