An institutional review of antimicrobial stewardship interventions.

Autor: Cao H; University of Houston College of Pharmacy, Houston, TX, USA., Phe K; University of Houston College of Pharmacy, Houston, TX, USA; Department of Pharmacy, Baylor St Luke's Medical Center, Houston, TX, USA., Laine GA; Department of Pharmacy, Baylor St Luke's Medical Center, Houston, TX, USA., Russo HR; Department of Pharmacy, Baylor St Luke's Medical Center, Houston, TX, USA., Putney KS; Department of Pharmacy, Baylor St Luke's Medical Center, Houston, TX, USA., Tam VH; University of Houston College of Pharmacy, Houston, TX, USA; Department of Pharmacy, Baylor St Luke's Medical Center, Houston, TX, USA. Electronic address: vtam@uh.edu.
Jazyk: angličtina
Zdroj: Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2016 Sep; Vol. 6, pp. 75-77. Date of Electronic Publication: 2016 May 04.
DOI: 10.1016/j.jgar.2016.03.006
Abstrakt: In order to combat increasing rates of bacterial resistance, many institutions have implemented antimicrobial stewardship programmes (ASPs) to improve antibiotic use. To ascertain the potential impact of our stewardship programme at Baylor St Luke's Medical Center (Houston, TX), antimicrobial-related interventions were analysed over a 4-year period. ASP recommendations related to antimicrobial therapy from 2009 to 2012 were retrieved from the hospital electronic database and were retrospectively reviewed. The number of interventions for each time period was adjusted to the hospital census data. The interventions were randomly assessed and categorised for clinical significance based on established institutional guidelines. In total, 14654 non-duplicate antimicrobial therapy interventions were retrieved, of which 11874 (81.0%) were audited for accuracy. Approximately 13 interventions were made per 1000 patient-days, but there were no significant patterns observed regarding the number of interventions performed from month to month (range 8-21). The most frequent types of interventions were related to inappropriate dosing (39.0%), antimicrobial selection (20.5%) and drug allergy (13.0%). Serious adverse drug events (ADEs) were potentially avoided in 20.7% of all interventions. Cumulative potential cost avoidance was more than US$6.5 million. In our institution, proper drug and dose selection were the major components of the ASP. Without focusing solely on reduction of drug acquisition costs, implementation of an ASP could still be cost effective by improving the quality of patient care and avoiding ADEs with serious consequences.
(Copyright © 2016 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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