| Autor: |
Ravindranath AJ; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. aditir@umich.edu., Cadigan KM; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. cadigan@umich.edu. |
| Jazyk: |
angličtina |
| Zdroj: |
Cancers [Cancers (Basel)] 2016 Aug 03; Vol. 8 (8). Date of Electronic Publication: 2016 Aug 03. |
| DOI: |
10.3390/cancers8080074 |
| Abstrakt: |
T-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans. TCFs recognize specific DNA sequences through their high mobility group (HMG) domains, but invertebrate TCFs and some isoforms of vertebrate TCF7 and TCF7L2 contain a second DNA binding domain known as the C-clamp. This review will cover the basic properties of C-clamps and their importance in Wnt signaling, using data from Drosophila, C. elegans, and mammalian cell culture. The connection between C-clamp containing TCFs and colorectal cancer will also be discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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