Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.

Autor: Wierzbicka JM; Department of Histology, Medical University of Gdańsk, Poland., Żmijewski MA; Department of Histology, Medical University of Gdańsk, Poland. Electronic address: mzmijewski@gumed.edu.pl., Piotrowska A; Department of Histology, Medical University of Gdańsk, Poland., Nedoszytko B; Department and Clinic of Dermatology, Venereology and Allergology, Medical University of Gdansk, Poland., Lange M; Department and Clinic of Dermatology, Venereology and Allergology, Medical University of Gdansk, Poland., Tuckey RC; School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Perth, WA 6009, Australia., Slominski AT; Department of Dermatology, University of Alabama Birmingham, Birmingham, AL 35294, USA; Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama Birmingham, Birmingham, AL 35294, USA; VA Medical Center, Birmingham, AL 35294, USA.
Jazyk: angličtina
Zdroj: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2016 Dec 05; Vol. 437, pp. 312-322. Date of Electronic Publication: 2016 Aug 12.
DOI: 10.1016/j.mce.2016.08.006
Abstrakt: Ultraviolet radiation B stimulates both the production of vitamin D 3 in the skin and the activation of the skin analog of the hypothalamic-pituitary-adrenal axis (HPA) as well as the central HPA. Since the role of vitamin D 3 in the regulation of the HPA is largely unknown, we investigated the impact of 1,25(OH) 2 D 3 and its noncalcemic analogs, 20(OH)D 3 and 21(OH)pD, on the expression of the local HPA in human epidermal keratinocytes. The noncalcemic analogs showed similar efficacy to 1,25(OH) 2 D 3 in stimulating the expression of neuropeptides, CRF, urocortins and POMC, and their receptors, CRFR1, CRFR2, MC1R, MC2R, MC3R and MC4R. Interestingly, unlike other secosteroids, the activity of 21(OH)pD did not correlate with induction of differentiation, suggesting a separate but overlapping mechanism of action. Thus, biologically active forms of vitamin D can regulate different elements of the local equivalent of the HPA with implications for the systemic HPA.
(Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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