Tributyltin chloride induces renal dysfunction by inflammation and oxidative stress in female rats.

Autor: Coutinho JV; Department of Morphology, Federal University of Espírito Santo, Brazil., Freitas-Lima LC; Department of Morphology, Federal University of Espírito Santo, Brazil., Freitas FF; Department of Physiological Sciences, Federal University of Espírito Santo, Brazil., Freitas FP; Department of Physiological Sciences, Federal University of Espírito Santo, Brazil., Podratz PL; Department of Morphology, Federal University of Espírito Santo, Brazil., Magnago RP; Department of Morphology, Federal University of Espírito Santo, Brazil., Porto ML; Department of Physiological Sciences, Federal University of Espírito Santo, Brazil., Meyrelles SS; Department of Physiological Sciences, Federal University of Espírito Santo, Brazil., Vasquez EC; Department of Physiological Sciences, Federal University of Espírito Santo, Brazil., Brandão PA; Department of Chemistry, Federal University of Espírito Santo, Brazil., Carneiro MT; Department of Chemistry, Federal University of Espírito Santo, Brazil., Paiva-Melo FD; Experimental Endocrinology Research Group, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil., Miranda-Alves L; Experimental Endocrinology Research Group, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil; Postgraduate Program in Endocrinology, School of Medicine, Federal University of Rio de Janeiro, Brazil., Silva IV; Department of Morphology, Federal University of Espírito Santo, Brazil., Gava AL; Department of Physiological Sciences, Federal University of Espírito Santo, Brazil. Electronic address: agatagava@hotmail.com., Graceli JB; Department of Morphology, Federal University of Espírito Santo, Brazil. Electronic address: jbgraceli@gmail.com.
Jazyk: angličtina
Zdroj: Toxicology letters [Toxicol Lett] 2016 Oct 17; Vol. 260, pp. 52-69. Date of Electronic Publication: 2016 Aug 10.
DOI: 10.1016/j.toxlet.2016.08.007
Abstrakt: Tributyltin chloride (TBT) is an organometallic pollutant that is used as a biocide in antifouling paints. TBT induces several toxic and endocrine-disrupting effects. However, studies evaluating the effects of TBT on renal function are rare. This study demonstrates that TBT exposure is responsible for improper renal function as well as the development of abnormal morphophysiology in mammalian kidneys. Female rats were treated with TBT, and their renal morphophysiology was assessed. Morphophysiological abnormalities such as decreased glomerular filtration rate and increased proteinuria levels were observed in TBT rats. In addition, increases in inflammation, collagen deposition and α-smooth muscle actin (α-SMA) protein expression were observed in TBT kidneys. A disrupted cellular redox balance and apoptosis in kidney tissue were also observed in TBT rats. TBT rats demonstrated reduced serum estrogen levels and estrogen receptor-α (ERα) protein expression in renal cortex. Together, these data provide in vivo evidence that TBT is toxic to normal renal function and that these effects may be associated with renal histopathology complications, such as inflammation and fibrosis.
(Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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