CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy.

Autor: Ulasov IV; Swedish Neuroscience Institute, Center for Advanced Brain Tumor Treatment, Seattle, WA, 98122, USA.; Institute of Experimental Diagnostics and Therapy of Tumors, N.N. Blokhin Russian Cancer Research Center, Moscow, 115478, Russia.; NN. Blokhin Cancer Research Center, RAMN, Moscow, 115478, Russia., Kaverina NV; NN. Blokhin Cancer Research Center, RAMN, Moscow, 115478, Russia.; Current employment: Division of Nephrology, University of Washington, Seattle, 98109, WA, USA., Ghosh D; Swedish Neuroscience Institute, Center for Advanced Brain Tumor Treatment, Seattle, WA, 98122, USA., Baryshnikova MA; Institute of Experimental Diagnostics and Therapy of Tumors, N.N. Blokhin Russian Cancer Research Center, Moscow, 115478, Russia.; NN. Blokhin Cancer Research Center, RAMN, Moscow, 115478, Russia., Kadagidze ZG; NN. Blokhin Cancer Research Center, RAMN, Moscow, 115478, Russia., Karseladze AI; NN. Blokhin Cancer Research Center, RAMN, Moscow, 115478, Russia., Baryshnikov AY; Institute of Experimental Diagnostics and Therapy of Tumors, N.N. Blokhin Russian Cancer Research Center, Moscow, 115478, Russia.; NN. Blokhin Cancer Research Center, RAMN, Moscow, 115478, Russia., Cobbs CS; Swedish Neuroscience Institute, Center for Advanced Brain Tumor Treatment, Seattle, WA, 98122, USA.
Jazyk: angličtina
Zdroj: Oncotarget [Oncotarget] 2017 Apr 18; Vol. 8 (16), pp. 25989-25999.
DOI: 10.18632/oncotarget.11175
Abstrakt: Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15-19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate and form neurospheres. At the molecular level, we show that CM70-3P increases expression of cellular SOX2. Collectively, these findings indicate that CMV70-3P is a potential regulator of CMV- mediated glioma progression and cancer stemness.
Databáze: MEDLINE
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