| Autor: |
Ferreira CR; Department of Chemistry and Center for Analytical Instrumentation Development (CAID), Purdue University, West Lafayette, IN 47907, USA. cooks@purdue.edu cferrei@purdue.edu., Yannell KE, Mollenhauer B, Espy RD, Cordeiro FB, Ouyang Z, Cooks RG |
| Jazyk: |
angličtina |
| Zdroj: |
The Analyst [Analyst] 2016 Sep 21; Vol. 141 (18), pp. 5252-5. Date of Electronic Publication: 2016 Aug 12. |
| DOI: |
10.1039/c6an01618a |
| Abstrakt: |
We report an accelerated biomarker discovery workflow and results of sample screening by mass spectrometry based on multiple reaction monitoring (MRM). This methodology shows promising initial results for the currently unsolved challenge of Parkinson's disease (PD) laboratory diagnosis by biomarker screening. Small molecules present in cerebrospinal fluid (CSF) at low parts per million levels are monitored using specific transitions connecting ion pairs. A set of such transitions constitutes a multidimensional chemical profile used to distinguish and characterize different CSF samples using multivariate statistical methods. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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