Phenotypic characterization of a pair of molecules in tissues confer to classical Mendelian or non Mendelian ratios.

Autor: Suneetha LM; CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India. Electronic address: drlavanyasuneetha@gmail.com., Marsakatla P; CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India., Ravi GV; CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India., Sykam A; CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India., Raju R; CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India., Reddy PP; Mahavir Medical Research Center, 37/165 BhagwanMahavir Marg, AC Guards, Masab Tank, Hyderabad 500028, India., Hara Gopal VV; Dept of Statistics, Osmania University, Hyderabad, India., Jadhav R; Government Institute of Science, Mumbai, India., Suneetha S; CODEWEL Nireekshana ACET, Narayanaguda, Hyderabad 500029, India.
Jazyk: angličtina
Zdroj: Medical hypotheses [Med Hypotheses] 2016 Sep; Vol. 94, pp. 112-7. Date of Electronic Publication: 2016 Jul 14.
DOI: 10.1016/j.mehy.2016.07.008
Abstrakt: Studies have reported a wide range of inflammatory responses in the nerve, skin and plasma of leprosy patients. The expression levels of each biomolecule was individualistic, however could be categorized as high and low based on their statistical mean level. Here we report for the first time, expression of a set of biomolecules relating with each other in a defined proportion. The hypothesis of this paper is that the segregation of high and low combinations of a set of biomolecules follows either classical Mendelian dihybrid ratio or epistatic ratios. This hypothesis was tested for 17 molecules in three tissues; nerve, skin and plasma and were confirmed to interact in 9:7, 9:3:4, 12:3:1, 13:3, 15:1 epistatic proportions. These findings suggest that there could be a significant role of networking of molecules in defined epistatic proportions and could be important in pathophysiology of peripheral nerve.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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