| Autor: |
Haynl C, Hofmann E, Pawar K, Förster S; Bayerisches Polymerinstitut (BPI) , Universitätsstraße 30, 95440 Bayreuth, Germany., Scheibel T; Bayerisches Polymerinstitut (BPI) , Universitätsstraße 30, 95440 Bayreuth, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Nano letters [Nano Lett] 2016 Sep 14; Vol. 16 (9), pp. 5917-22. Date of Electronic Publication: 2016 Aug 12. |
| DOI: |
10.1021/acs.nanolett.6b02828 |
| Abstrakt: |
Collagens are widely used as biomaterials in drug-delivery and tissue engineering applications due to their biodegradability, biocompatibility and hypoallergenicity. Besides gelatin-based materials, collagen microfibers are in the focus of biomedical research. Commonly, man-made fibers are produced by wet-spinning yielding fiber diameters higher than 8 μm. Here, assembly and continuous production of single collagen type I microfibers were established using a microfluidic chip. Microfluidics-produced microfibers exhibited tensile strength and Young's modulus exceeding that of fibers produced in classical wet-spinning devices and even that of natural tendon and they showed lower diameters. Their structural orientation was examined by polarized Fourier transform infrared spectroscopy (FTIR) showing fibril alignment within the microfiber. Cell culture tests using the neuronal cell line NG108-15 showed cell alignment and axon growth along the microfiber axes inaugurating potential applications in, for example, peripheral nerve repair. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
