The effect of pregabalin - codeine combination on partial sciatic nerve ligation - induced peripheral mononeuropathy in rats.

Autor:	Popa G; University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Pharmacy, Department of Pharmaceutical Technology, Iasi, Romania., Mititelu Tartau L; University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Medicine, Department of Pharmacology-Algesiology, Iasi, Romania. lylytartau@yahoo.com., Stoleriu I; University 'Al.I. Cuza', Faculty of Mathematics, Iasi, Romania., Lupusoru RV; University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Medicine, Department of Patho-Physiology, Iasi, Romania., Lupusoru CE; University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Medicine, Department of Pharmacology-Algesiology, Iasi, Romania., Ochiuz L; University of Medicine and Pharmacy 'Grigore T. Popa', Faculty of Pharmacy, Department of Pharmaceutical Technology, Iasi, Romania.
Jazyk:	angličtina
Zdroj:	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society [J Physiol Pharmacol] 2016 Jun; Vol. 67 (3), pp. 465-9.
Abstrakt:	The present study investigates the effects of pregabalin (PGB) and codeine (COD) combination on neuropathic hyperalgesia in an animal model of peripheral nerve injury represented by partial sciatic nerve ligation. Hot plate and analgesimeter tests were performed to evaluate the influence of PGB, COD and their combination on thermal and mechanical hyperalgesia in the hind paw with partial sciatic nerve ligation. Reactivity was evaluated by measuring the latency to withdrawal of the operated hind paw from the noxious heat and pressure stimulation. Nociceptive thresholds were evaluated before (baseline) and in the 1(st), 3(rd), 5(th) and 7(th) day after surgical procedure. The investigation demonstrates that the treatment with PGB attenuated partial sciatic nerve ligation development of thermal and mechanical hyperalgesia in rats operated hind paw. The oral administration, during 14 consecutive days of PGB-COD combination significantly reduced the degree of both thermal and mechanical hyperalgesia in the hind paw with partial sciatic nerve ligation. These results suggest that the association of PGB with COD exerted ameliorative effect on partial sciatic nerve ligation-induced neuropathic pain in rats.
Databáze:	MEDLINE
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