Untreated hepatocellular carcinoma in Egypt: outcome and prognostic factors.

Autor:	Zeeneldin AA; Medical Oncology/Hematology, National Cancer Institute, Cairo University, Cairo, Egypt., Salem SE; Medical Oncology/Hematology, National Cancer Institute, Cairo University, Cairo, Egypt., Darwish AD; Medical Oncology/Hematology, National Cancer Institute, Cairo University, Cairo, Egypt., El-Gammal MM; Medical Oncology/Hematology, National Cancer Institute, Cairo University, Cairo, Egypt., Hussein MM; Medical Oncology/Hematology, National Cancer Institute, Cairo University, Cairo, Egypt., Saadeldin M; Medical Oncology, Tanta Cancer Center, Tanta, Egypt.
Jazyk:	angličtina
Zdroj:	Journal of hepatocellular carcinoma [J Hepatocell Carcinoma] 2015 Jan 30; Vol. 2, pp. 3-9. Date of Electronic Publication: 2015 Jan 30 (Print Publication: 2015).
DOI:	10.2147/JHC.S73828
Abstrakt:	Background: Hepatocellular carcinoma (HCC) is a common cancer worldwide as well as in Egypt with hepatitis C and B, alcohol and aflatoxins being the commonest risk factors. Aim: The objective of this study was to assess the prognostic factors affecting overall survival (OS) of untreated HCC in Egypt. Methods: This retrospective study was conducted at Tanta Cancer Center, Egypt where 288 HCC cases who received no specific therapy and were followed-up until death were identified. The impact of possible prognostic factors on OS was assessed using the log-rank test (univariate analyses) and Cox regression method (multivariate analysis). Results: The median OS of untreated HCC was 2.3 months (95% confidence interval: 1.9-2.6). The 1, 3, 6, 12, 24 months OS rates were 84%, 42%, 21%, 9%, and 3%, respectively. All cases had died by 46 months. Male sex, advanced Child-Pugh class, the clinical presentation of ascites, cough, fatigue, and the presence of metastases were associated with poor survival (P<0.05 for all). In multivariate analysis; cough, presence of ascites, and Child-Pugh class were independent predictors of poor survival. Conclusion: OS in untreated HCC in Egypt is very short. Many factors interact to produce this dismal survival.
Databáze:	MEDLINE
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