First Report of the Globally Disseminated IncX4 Plasmid Carrying the mcr-1 Gene in a Colistin-Resistant Escherichia coli Sequence Type 101 Isolate from a Human Infection in Brazil.

Autor:	Fernandes MR; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil miriamrfernandes@usp.br lincopan@usp.br., McCulloch JA; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Vianello MA; Hospital de Guarnição de Natal, Brazilian Army, Natal, Brazil., Moura Q; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Pérez-Chaparro PJ; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Esposito F; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Sartori L; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Dropa M; School of Public Health, University of São Paulo, São Paulo, Brazil., Matté MH; School of Public Health, University of São Paulo, São Paulo, Brazil., Lira DP; Hospital de Guarnição de Natal, Brazilian Army, Natal, Brazil., Mamizuka EM; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Lincopan N; Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil miriamrfernandes@usp.br lincopan@usp.br.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Sep 23; Vol. 60 (10), pp. 6415-7. Date of Electronic Publication: 2016 Sep 23 (Print Publication: 2016).
DOI:	10.1128/AAC.01325-16
Abstrakt:	A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 plasmids that were recently identified in Enterobacteriaceae from food, animal, and human samples recovered on different continents. These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene. (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)
Databáze:	MEDLINE
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