Natural Products and the Gene Cluster Revolution.

Autor: Jensen PR; Center for Marine Biotechnology and Biomedicine, Center for Microbiome Innovation, Scripps Institution of Oceanography, University of California San Diego, San Diego, California, USA. Electronic address: pjensen@ucsd.edu.
Jazyk: angličtina
Zdroj: Trends in microbiology [Trends Microbiol] 2016 Dec; Vol. 24 (12), pp. 968-977. Date of Electronic Publication: 2016 Aug 01.
DOI: 10.1016/j.tim.2016.07.006
Abstrakt: Genome sequencing has created unprecedented opportunities for natural-product discovery and new insight into the diversity and distributions of natural-product biosynthetic gene clusters (BGCs). These gene collectives are highly evolved for horizontal exchange, thus providing immediate opportunities to test the effects of small molecules on fitness. The marine actinomycete genus Salinispora maintains extraordinary levels of BGC diversity and has become a useful model for studies of secondary metabolism. Most Salinispora BGCs are observed infrequently, resulting in high population-level diversity while conforming to constraints associated with maximum genome size. Comparative genomics is providing a mechanism to assess secondary metabolism in the context of evolution and evidence that some products represent ecotype-defining traits while others appear selectively neutral.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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