Infectious Complications after Major Abdominal Cancer Surgery: In Search of Improvable Risk Factors.

Autor:	Smit LC; 1 Laboratory of Clinical Microbiology and Infectious Diseases , Isala, Zwolle, The Netherlands ., Bruins MJ; 1 Laboratory of Clinical Microbiology and Infectious Diseases , Isala, Zwolle, The Netherlands ., Patijn GA; 2 Department of Surgery, Isala, Zwolle, The Netherlands ., Ruijs GJ; 1 Laboratory of Clinical Microbiology and Infectious Diseases , Isala, Zwolle, The Netherlands .
Jazyk:	angličtina
Zdroj:	Surgical infections [Surg Infect (Larchmt)] 2016 Dec; Vol. 17 (6), pp. 683-693. Date of Electronic Publication: 2016 Aug 02.
DOI:	10.1089/sur.2016.033
Abstrakt:	Background: Major resections for esophageal, gastric, hepatic, pancreatic, and colorectal cancer continue to be associated with a high peri-operative morbidity of up to 30%-40%. To a large extent, this morbidity is caused by infectious complications that add up to a considerable burden to patients and hospital costs. The objective of this large retrospective cross-sectional study was to determine independent patient and operation-related risk factors for infectious complications after major abdominal cancer operations to elucidate how infection rates can be reduced and improve health-care quality. Patients and Methods: In 1,389 cancer patients who underwent a major resection procedure between 2009 and 2013, infectious complications and their independent determinants were analyzed by multivariable logistic regression (p < 0.05). Results: Male gender was a risk factor for infections in general, whereas patients ≥65 y (odds ratio [OR] 1.75; p = 0.008), urinary tract infection (OR 0.51; p = 0.004), American Society of Anesthesiologists score (OR 1.55; p = 0.004), overall (OR 1.70; p = 0.037), vascular (OR 1.59; p = 0.020), and neurologic comorbidity (OR 2.22; p = 0.001) were associated significantly with pneumonia. Intra-abdominal drainage (OR 1.41; p = 0.024) and a duration of surgery of ≥180 min (OR 1.85; p = 0.001) were risk factors for surgical site infections. Total parenteral nutrition was significantly associated with intravascular catheter-induced infections (OR 18.09; p < 0.001) and sepsis (OR 6.69; p < 0.001). Conclusions: In this study, several independent risk factors for infectious complications in major abdominal cancer operations were identified, providing opportunities for further reducing peri-operative infections. General awareness and focus on preventing infectious complications may have a significant impact on health-care outcomes and costs.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu