Analysis of cytokine gene polymorphisms in Mestizo and native populations from Mexico.

Autor: Mendoza-Carrera F; Molecular Medicine Division, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (CIBO-IMSS), Guadalajara, Jal. México., Castro-Martínez XH; Molecular Medicine Division, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (CIBO-IMSS), Guadalajara, Jal. México., Leal C; Surgical Research Division, CIBO-IMSS, Guadalajara, Jal. México., Portilla-de Buen E; Surgical Research Division, CIBO-IMSS, Guadalajara, Jal. México., Sánchez-Corona J; Molecular Medicine Division, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (CIBO-IMSS), Guadalajara, Jal. México., Flores-Martínez SE; Molecular Medicine Division, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (CIBO-IMSS), Guadalajara, Jal. México., García-Zapién A; Molecular Medicine Division, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (CIBO-IMSS), Guadalajara, Jal. México., Ramírez-López G; Unidad de Investigación Epidemiológica y en Servicios de Salud del Adolescente, IMSS, Tonalá, Jal. México., Gómez-Espinel I; Departamento de Patología Clínica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, N.L, México., Báez-Duarte BG; Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Pue, México., Zamora-Ginez I; Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Pue, México., Velarde-Félix JS; Cuerpo Académico Inmunogenética y Evolución UAS-CA-265, Unidad Académica Escuela de Biología, Universidad Autónoma de Sinaloa, Culiacán, Sin, México., Guillermo Sánchez-Zazueta J; Cuerpo Académico Inmunogenética y Evolución UAS-CA-265, Unidad Académica Escuela de Biología, Universidad Autónoma de Sinaloa, Culiacán, Sin, México.
Jazyk: angličtina
Zdroj: American journal of human biology : the official journal of the Human Biology Council [Am J Hum Biol] 2017 Jan; Vol. 29 (1). Date of Electronic Publication: 2016 Aug 02.
DOI: 10.1002/ajhb.22900
Abstrakt: Objectives: To determine whether the well-known genetic structure of the Mexican population observed with other multiallelic markers can be detected by analyzing functional polymorphisms of cytokine and other inflammatory-response-related genes.
Methods: A total of 834 Mestizo individuals from five Mexican cities and 92 Lacandonians - an Amerindian group from southeastern Mexico - were genotyped for 14 polymorphisms in the CRP, IL10, IL6, TGFB1, TNFA, LTA, ICAM1 IFNG, and IL1RN genes. Allele and haplotype frequencies were used for genetic structure analysis using F-statistics pairwise distances and multidimensional scaling plot. Ancestry analysis was performed, as well.
Results: Significant interpopulational differences at the allele and haplotype frequency level were observed, mainly between Northern (Guadalajara, Monterrey, and Culiacan) and Southern (Tierra Blanca and Puebla) Mexican populations. Also, low but significant substructure was detected between some populations from these two broad regions. Interestingly, both Lacandonian populations were highly differentiated from each other and with respect to Mestizos. Consistent with previous data, Amerindian ancestry in the Southern Mexican groups was higher compared to Northern ones.
Conclusions: The Mexican population exhibits regional differences in functional polymorphisms of inflammatory-response genes, as observed for other genetic markers. This information constitutes a reference for epidemiological studies that include these genetic markers to assess the susceptibility of the Mexican population to several immune-response-related diseases, such as diabetes, obesity, and renal disease, which have been shown to be common in the Mexican population but with prevalence differences within this country.
(© 2016 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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