The Effect of TNF-α Blocker HL036337 and Its Best Concentration to Inhibit Dry Eye Inflammation.

Autor:	Choi W; Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea., Noh H; Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea., Yeo A; Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea., Jang H; Noksibcho Hospital, Seoul, Korea., Ahn HK; HanAll Biopharma, Seoul, Korea., Song YJ; HanAll Biopharma, Seoul, Korea., Lee HK; Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
Jazyk:	angličtina
Zdroj:	Korean journal of ophthalmology : KJO [Korean J Ophthalmol] 2016 Aug; Vol. 30 (4), pp. 302-8. Date of Electronic Publication: 2016 Jul 21.
DOI:	10.3341/kjo.2016.30.4.302
Abstrakt:	Purpose: Dry eye syndrome is commonly thought of as an inflammatory disease, and we have previously presented data showing the effectiveness of topical TNF-α blocker agents for the treatment of this condition. The purpose of this study was to investigate the effectiveness of the TNF-α blocking agent HL036337 compared to cyclosporine A for the treatment of dry eye induced inflammation in order to establish whether HL036337 represents a more effective method for suppressing inflammation. The efficacy of HL036337 and cyclosporine A was determined using an experimental murine dry eye model. Methods: The TNF-α blocker HL036337 is a modified form of TNF receptor I. Using dry eye induced C57BL/6 mice (n = 45), corneal erosion was measured at day 4 and 7 after topical treatment with cyclosporine A or HL036337. To determine the effective treatment dose, 0.25, 0.5, 1, 2.5, and 5 mg/mL of HL036337 were topically administered twice per day to dry eye induced murine corneas for 1 week. Results: The optimal concentration of the TNF-α blocker HL036337 for treatment of dry eye induced corneal erosion was determined to be 1 mg/mL. Dry eye induced corneal erosion was improved after 1 week with topically applied cyclosporine A and HL036337 at 1 mg/mL. Conclusions: HL036337 administered topically at 1 mg/mL effectively improved corneal erosion induced by dry eye. This finding may also suggest that inhibition of TNF-α can improve dry eye syndrome.
Databáze:	MEDLINE
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