Role of the suppressor of cytokine signaling 2 (SOCS2) during meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5).

Autor: Aparecida Silva Barbosa A; Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: alinesb.bio@gmail.com., Freitas Versiani A; Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: alicefv_vet@yahoo.com.br., Fonseca da Cunha Sousa L; Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: laris.fonseca@gmail.com., Silva de Miranda A; Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: mirandas.aline@gmail.com., Gasparini MR; Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: marcela.gasparini@pirbright.ac.uk., Brant F; Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: fatimacbrant@gmail.com., Silva DG; Departamentos de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: danivets@gmail.com., Luisa Quintino-de-Carvalho I; Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: iracemaluisa@yahoo.com.br., Marianetti Soriani F; Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: fredsori@gmail.com., Guimarães da Fonseca F; Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: fdafonseca@cpqrr.fiocruz.br., César Vasconcelos A; Departamentos de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: anilton@icb.ufmg.br., da Silva Barcelos L; Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: aloicul@yahoo.com., Martins Teixeira M; Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: mmtex.ufmg@gmail.com., Lúcio Teixeira A; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Texas Health Science Center at Houston, TX, USA. Electronic address: altexr@gmail.com., Machado FS; Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: machadofs@gmail.com., Barbosa-Stancioli EF; Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: edelfb@icb.ufmg.br., Rachid MA; Departamentos de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, MG, Brazil. Electronic address: milenerachid@gmail.com.
Jazyk: angličtina
Zdroj: Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2016 Aug; Vol. 47, pp. 26-31. Date of Electronic Publication: 2016 May 18.
DOI: 10.1016/j.cimid.2016.05.003
Abstrakt: The role of suppressors of cytokine signaling (SOCS) in meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5) was evaluated by intracranial infection in C57BL/6 wild-type mice (WT) and SOCS2 deficient mice (SOCS2(-/-)). Both infected groups presented weight loss, ruffled fur and hunched posture. Additionally, infected SOCS2(-/-) mice showed swollen chamfer and progressive depression. Infected WT animals developed mild meningitis, characterized by infiltration of mononuclear cells. Moreover, viral DNA was detected in liver and lung from infected WT group. This group also showed elevated brain levels of IFN-γ, IL-10, CXCL1 and CCL5, when compared with non-infected WT animals. Brain inflammation was exacerbated in infected SOCS2(-/-) mice with widespread distribution of the virus and increased brain levels of TNF-α, IFN-γ, IL-10, IL-12, CXCL1 and CCL5, when compared with WT infected mice. Moreover, infected SOCS2 deficient mice exhibited reduced brain mRNA expression of IFNα and IFNβ and increased expression of mRNA of SOCS1, compared with infected WT mice. Taken together, our study provides an insight into the role of SOCS2 in modulating the immune response to BoHV-5 infection.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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