Shipping Drug Resistance: Extracellular Vesicles in Ovarian Cancer.

Autor: Strandmann EPV; Innate Immunity Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Experimental Tumor Research, Center for Tumor Biology and Immunology, Clinic for Hematology, Oncology, and Immunology, Philipps University, Hans-Meerwein-Strasse 3, 35043 Marburg, Germany. Electronic address: elke.pogge@uk-koeln.de., Müller R; Institute of Molecular Biology and Tumor Research, Center for Tumor Biology and Immunology, Philipps University, Hans-Meerwein-Strasse 3, 35043 Marburg, Germany.
Jazyk: angličtina
Zdroj: Trends in molecular medicine [Trends Mol Med] 2016 Sep; Vol. 22 (9), pp. 741-743. Date of Electronic Publication: 2016 Jul 26.
DOI: 10.1016/j.molmed.2016.07.006
Abstrakt: Ovarian cancer is a deadly disease, largely because of relapse and chemotherapy resistance. Common genetic mechanisms causing drug resistance have not been identified. A recent study unravels a novel and unexpected pathway involving the transfer of microvesicle-encapsulated miRNA from omental adipocytes and fibroblasts, to cancer cells.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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