MUNIX: Reproducibility and clinical correlations in Amyotrophic Lateral Sclerosis.

Autor: Escorcio-Bezerra ML; Department of Neurology, Universidade Federal de São Paulo, SP, Brazil. Electronic address: marciobzrra@gmail.com., Abrahao A; Department of Neurology, Universidade Federal de São Paulo, SP, Brazil., de Castro I; Department of Medicine, Division of Molecular Medicine, University of São Paulo School of Medicine (FMUSP), Brazil., Chieia MAT; Department of Neurology, Universidade Federal de São Paulo, SP, Brazil., de Azevedo LA; Department of Neurology, Universidade Federal de São Paulo, SP, Brazil., Pinheiro DS; Department of Neurology, Universidade Federal de São Paulo, SP, Brazil., de Oliveira Braga NI; Department of Neurology, Universidade Federal de São Paulo, SP, Brazil., de Oliveira ASB; Department of Neurology, Universidade Federal de São Paulo, SP, Brazil., Manzano GM; Department of Neurology, Universidade Federal de São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2016 Sep; Vol. 127 (9), pp. 2979-2984. Date of Electronic Publication: 2016 Jun 23.
DOI: 10.1016/j.clinph.2016.06.011
Abstrakt: Objective: To study the reproducibility, diagnostic yield to detect denervation, and clinical correlations of the Motor Unit Number Index (MUNIX) in subjects with Amyotrophic Lateral Sclerosis (ALS).
Methods: MUNIX evaluation was performed in three muscles twice on the same day to assess reproducibility. Cut-off values for the MUNIX were based on data from 51 healthy subjects (controls) to evaluate the sensitivity of the technique to detect denervation in 30 subjects with ALS.
Results: The method had good reproducibility. The variability was greater in the ALS group. In 23 ALS subjects (77%), low MUNIX values were detected. Most of the muscles with low MUNIX had also low compound muscle action potential (CMAP) and strength, but these parameters were normal in 9% of muscles. According to ROC curve analysis, MUNIX was generally accurate (AUC=0.9504) for discriminating between healthy individuals and subjects with at least one denervated muscle.
Conclusions: MUNIX variability was higher in the ALS group. The method showed good diagnostic performance for the detection of denervation in a sample of patients with ALS.
Significance: This study demonstrated that in addition to being a quantitative tool MUNIX can detect denervation in subjects with ALS.
(Copyright © 2016 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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