[A study of the effect of the genes of inflammatory proteins on basic personality dimensions].

Autor:	Golimbet VE; Mental Health Research Center, Moscow, Russia., Alfimova MV; Mental Health Research Center, Moscow, Russia., Korovaitseva GI; Mental Health Research Center, Moscow, Russia., Lezheiko TV; Mental Health Research Center, Moscow, Russia., Kondratyev NV; Mental Health Research Center, Moscow, Russia., Krikova EV; Mental Health Research Center, Moscow, Russia., Gabaeva MV; Mental Health Research Center, Moscow, Russia., Kasparov SV; Mental Health Research Center, Moscow, Russia., Kolesina NY; Mental Health Research Center, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2016; Vol. 116 (6), pp. 48-52.
DOI:	10.17116/jnevro20161166148-52
Abstrakt:	Aim: The present research examines the association between two basic dimensions of personality and genes of inflammatory cytokines and mediators reported to be elevated in schizophrenia and affective disorders. Genes of interleukin-1B (IL-1B), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP) and alpha 1-antitrypsin (A1AT) were studied. Material and Methods: A total of 639 healthy subjects, aged from 17 to 69 years, participated in the study. The following polymorphisms were genotyped: IL-1B С-511Т (rs16944) and С3954Т (rs1143634), IL-6 G-174C (rs1800795), TNF-α G-308A (rs1800629), CRP (rs279452), A1AT 374G/A (rs709932). Basic personality dimensions Extraversion and Neuroticism were assessed using the Eysenck Personality Inventory. Results and Conclusion: The levels of Extraversion and Neuroticism were not associated with IL-1B, IL-6, TNF-α G and CRP polymorphisms. The association between the A1AT 374G/A polymorphism and Extraversion (р=0.036) was shown. There was a trend towards the association between the A1AT 374G/A polymorphism and Neuroticism (p=0,05) in women. Because this is the first study of the effect of IL-1B, IL-6, TNF-α and A1AT on personality dimensions, the results should be considered as preliminary and need to be replicated.
Databáze:	MEDLINE
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