Association of a promoter polymorphism in FSHR with ovarian reserve and response to ovarian stimulation in women undergoing assisted reproductive treatment.

Autor: Tohlob D; Manchester Centre for Genomic Medicine, University of Manchester, Manchester, United Kingdom; Clinical Pathology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt., Abo Hashem E; Clinical Pathology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt., Ghareeb N; Clinical Pathology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt., Ghanem M; Obstetrics and Gynaecology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt., Elfarahaty R; Clinical Pathology Department, Faculty of Medicine, Mansoura University Mansoura, Egypt., Byers H; Manchester Centre for Genomic Medicine, University of Manchester, Manchester, United Kingdom., Pemberton P; Department of Clinical Biochemistry, Manchester Royal Infirmary, Manchester, United Kingdom., Roberts SA; Centre for Biostatistics, Institute of Population Health, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester, United Kingdom., Newman WG; Manchester Centre for Genomic Medicine, University of Manchester, Manchester, United Kingdom., Mohiyiddeen L; Department of Reproductive Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom. Electronic address: Lamiya.Mohiyiddeen@cmft.nhs.uk.
Jazyk: angličtina
Zdroj: Reproductive biomedicine online [Reprod Biomed Online] 2016 Sep; Vol. 33 (3), pp. 391-7. Date of Electronic Publication: 2016 Jun 17.
DOI: 10.1016/j.rbmo.2016.06.001
Abstrakt: Previous studies have suggested an association between a variant in the promoter region of the FSHR gene and diminished response to controlled ovarian hyperstimulation (COH) in women undergoing assisted reproduction. FSHR -29G>A was genotyped in 559 women undergoing their first cycle of COH for IVF/intracytoplasmic sperm injection (ICSI) using TaqMan allelic discrimination assay. Correlation and regression analysis was performed to assess the relationship between FSHR promoter genotypes and markers of ovarian reserve and measures of response to COH, including the number of oocytes retrieved, gonadotrophin dose used and the live-birth rate. There were no statistically significant differences between the genotype frequencies and the markers of ovarian reserve or the early measures of response to COH. However, the live-birth rate was higher for women carrying the variant A allele (odds ratio [OR] 1.37; 95% confidence interval [CI] 1.02-1.84 per allele). This relationship did not reach statistical significance after adjustment for the number of embryos transferred (OR 1.33; 95% CI 0.98-1.83 per allele). Results from this study do not provide evidence that the FSHR -29G>A variant can be used in the individualization of the treatment protocol for women undergoing IVF/ICSI.
(Copyright © 2016. Published by Elsevier Ltd.)
Databáze: MEDLINE
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