| Autor: |
Brill N; Fraunhofer Institute for Production Technology, Steinbachstraße 17, Aachen 52074, Germany., Wirtz M; Fraunhofer Institute for Production Technology, Steinbachstraße 17, Aachen 52074, Germany., Merhof D; RWTH Aachen University, Institute of Imaging and Computer Vision, Kopernikusstraße 16, Aachen 52074, Germany., Tingart M; Aachen University Hospital, Department of Orthopaedic Surgery, Pauwelsstraße 30, Aachen 52074, Germany., Jahr H; Aachen University Hospital, Department of Orthopaedic Surgery, Pauwelsstraße 30, Aachen 52074, Germany., Truhn D; Aachen University Hospital, Department of Diagnostic and Interventional Radiology, Pauwelsstraße 30, Aachen 52074, Germany., Schmitt R; Fraunhofer Institute for Production Technology, Steinbachstraße 17, Aachen 52074, GermanyeRWTH Aachen University, Laboratory for Machine Tools and Production Engineering, Manfred-Weck Haus, Steinbachstraße 19, Aachen 52074, Germany., Nebelung S; Aachen University Hospital, Department of Diagnostic and Interventional Radiology, Pauwelsstraße 30, Aachen 52074, Germany. |
| Abstrakt: |
Polarization-sensitive optical coherence tomography (PS-OCT) is a light-based, high-resolution, real-time, noninvasive, and nondestructive imaging modality yielding quasimicroscopic cross-sectional images of cartilage. As yet, comprehensive parameterization and quantification of birefringence and tissue properties have not been performed on human cartilage. PS-OCT and algorithm-based image analysis were used to objectively grade human cartilage degeneration in terms of surface irregularity, tissue homogeneity, signal attenuation, as well as birefringence coefficient and band width, height, depth, and number. Degeneration-dependent changes were noted for the former three parameters exclusively, thereby questioning the diagnostic value of PS-OCT in the assessment of human cartilage degeneration. |
