| Autor: |
Conger JL; From the *Cardiovascular Research Laboratories, Texas Heart Institute, Houston, Texas; and †Vitalmex Internacional SA de CV, Mexico City, Mexico., Grace BW, Van Noy KL, Handy KM, Costas GG, Rodriguez-Sierra CA, Trejo A, Pinzon J, Cohn WE |
| Jazyk: |
angličtina |
| Zdroj: |
ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2016 Nov/Dec; Vol. 62 (6), pp. 697-703. |
| DOI: |
10.1097/MAT.0000000000000417 |
| Abstrakt: |
In a previous study, we showed that the Vitalmex Extracorporeal Ventricular Assist Device-Pneumatic (EVAD-P)-a low-cost, pneumatically actuated, pulsatile blood pump-is easy to implant and safe for short-term in vivo support (30 ± 5 days). In the current study, we included additional 30 day experiments and assessed the safety and durability of the EVAD-P for up to 90 days of support. Using the same surgical procedure as in the previous study, we implanted the device into 14 healthy sheep. Group I subjects (n = 7) were evaluated for up to 30 days, and group II (n = 2) and group III (n = 5) subjects were evaluated for up to 49 and 93 days, respectively. After a system redesign, two of the five sheep in group III reached the scheduled end-point without device-related problems at a fixed beat rate of 56 bpm, a stroke volume (SV) of 58.0 ± 2.3 ml, and a flow of 3.5 ± 0.2 L/min. This study shows that the EVAD-P can provide safe pulsatile mechanical circulatory support (MCS) for up to 93 days. To further confirm that the system can consistently provide MCS for this duration, additional studies are recommended. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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